Table of Contents
Summary:
Polynucleotide treatment is a regenerative injectable treatment designed to improve skin quality rather than add volume. By stimulating cellular repair, collagen production and hydration, polynucleotides can help improve fine lines, skin texture, elasticity and under-eye concerns.
Results develop gradually and are often chosen by patients seeking natural-looking skin rejuvenation without changing their facial features.
What Is a Polynucleotide Treatment?
Over recent years, aesthetic medicine has shifted towards treatments that focus on regeneration rather than simply replacing lost volume.
Polynucleotide treatment is one of the most exciting developments in this area. Polynucleotides are naturally occurring chains of nucleotides that help support tissue repair and cellular function. When injected into the skin, they act as biological messengers, encouraging the skin to repair itself and function more effectively.
Unlike traditional fillers, polynucleotides are not designed to add volume or alter facial contours. Instead, they focus on improving the quality of the skin itself.
For many patients, this makes them an attractive option for natural-looking rejuvenation.
At Swiss Aesthetics, we use REJURAN®, one of South Korea’s leading polynucleotide treatments. REJURAN® contains highly purified polynucleotides derived from wild salmon DNA and is designed to support skin regeneration, hydration and collagen production.
How Do Polynucleotide Injections Work?
Polynucleotides work by stimulating the skin’s natural regenerative processes.
Following treatment, they help encourage fibroblast activity, which plays an important role in collagen and elastin production. They also support hydration, tissue repair and the skin’s ability to recover from environmental stress and ageing.
The polynucleotides used in REJURAN® act as a biological repair signal within the skin, helping create an environment that supports cellular regeneration and long-term skin health. They also attract water into the tissues, helping improve hydration alongside collagen stimulation.
As collagen levels improve, the skin gradually becomes firmer, smoother and more resilient.
Because the treatment works through regeneration rather than volume replacement, results tend to develop progressively over several weeks.
Benefits of Polynucleotide Treatment
Some of the most commonly reported benefits include:
- Improved skin texture and elasticity
- Increased hydration
- Softening of fine lines
- Support for collagen production
- Natural-looking skin rejuvenation
Patients often choose polynucleotides because they improve overall skin quality without creating an overfilled appearance.
Polynucleotides Under Eyes
One of the most popular treatment areas for polynucleotides is the delicate under-eye region.
The skin beneath the eyes is thinner than elsewhere on the face and is often one of the first areas to show signs of ageing. Fine lines, crepey skin, dark circles and loss of skin quality can all contribute to a tired appearance.
Polynucleotides can help improve this area by supporting hydration, collagen production and tissue repair. Rather than filling the under-eye area, the treatment focuses on improving the condition of the skin itself.
For patients who are not suitable for tear trough fillers or who want a more regenerative approach, polynucleotides can provide an alternative option worth considering.
Looking for a treatment specifically designed to address volume loss and hollowness beneath the eyes? Learn more about our Tear Trough treatment.
Polynucleotides vs Profhilo
Patients frequently ask how polynucleotides compare with Profhilo.
While both treatments are used for skin rejuvenation, they work differently.
| Treatment | Primary Goal | How It Works |
| Polynucleotides | Regeneration and repair | Stimulates cellular repair and collagen production |
| Profhilo | Hydration and skin quality | Delivers high concentrations of hyaluronic acid |
| Dermal Fillers | Volume restoration | Replaces lost volume and enhances facial contours |
Profhilo is often chosen when hydration and skin quality are the primary concerns, while polynucleotides may be more suitable for patients looking to support regeneration and tissue repair.
In some cases, the treatments can complement one another as part of a broader treatment plan.
How Do Polynucleotides Compare to Dermal Fillers?
One of the biggest misconceptions about polynucleotides is that they work like fillers.
Dermal fillers are designed to restore volume, contour facial features and address structural changes associated with ageing. Polynucleotides work differently.
Rather than adding volume, they aim to improve the condition of the skin itself. This makes them particularly attractive for patients who want subtle rejuvenation without changing their facial shape.
In our experience, patients seeking a refreshed appearance often appreciate the natural-looking results that regenerative treatments can provide.
What Results Can You Expect?
Polynucleotide treatment is designed to deliver gradual improvements rather than instant transformation.
Many patients begin noticing changes in skin hydration and texture within the first few weeks. As collagen production increases, further improvements often become visible over the following months.
Potential outcomes may include improved elasticity, smoother texture, better hydration and healthier-looking skin overall.
At Swiss Aesthetics, we typically recommend a course of three treatments for optimal results. Improvements usually develop gradually as the skin’s natural regenerative processes respond to treatment.
As with any regenerative treatment, results vary between individuals and are influenced by factors such as age, skin condition and lifestyle.
Who Is Suitable for Polynucleotide Treatment?
Polynucleotides may be suitable for patients who:
Want natural-looking rejuvenation
Are concerned about skin quality rather than volume loss
Have fine lines, crepey skin or early signs of ageing
Are looking to improve the under-eye area
Prefer regenerative treatments that work gradually
Many patients choose polynucleotides because they fit well within a long-term skin health strategy rather than acting as a quick cosmetic fix.
Who Is It Not For?
Polynucleotide treatment may not be ideal for patients seeking immediate volume enhancement or dramatic facial reshaping.
Those looking to replace significant volume loss may be better suited to dermal fillers or a combination treatment approach.
A professional consultation is always recommended to determine the most appropriate treatment plan based on individual concerns and goals.
Are Polynucleotides Safe?
Polynucleotides are generally considered safe when administered by appropriately trained medical professionals.
As with most injectable treatments, temporary redness, swelling or bruising may occur at the injection sites. These effects are typically mild and resolve within a few days.
A consultation and full medical assessment are essential before treatment to ensure suitability.
Final Thoughts
Polynucleotide treatment represents a different approach to aesthetic medicine.
Rather than focusing on adding volume or dramatically altering facial features, it supports the skin’s own regenerative processes to improve quality, hydration and resilience over time.
For patients seeking natural-looking rejuvenation, healthier skin and long-term improvements in skin quality, polynucleotides can be an excellent option to explore.
Regeneration. Hydration. Healthier-looking skin.
Polynucleotides are just one of several regenerative injectable treatments available at Swiss Aesthetics. Explore our full range of injectable treatments.
FAQ’s
Are polynucleotides better than Profhilo?
Neither treatment is universally better. Profhilo primarily focuses on hydration, while polynucleotides focus on regeneration, repair and collagen stimulation. The most suitable option depends on your concerns and goals.
Are polynucleotide injections painful?
Most patients tolerate treatment well. Some mild discomfort can occur during injections, but the procedure is generally considered minimally invasive.
Are polynucleotides worth it?
For patients looking to improve skin quality naturally and gradually, polynucleotides can be a valuable addition to a long-term skin rejuvenation plan.
Is Polynucleotide Treatment Made From Salmon DNA?
Yes. REJURAN® contains highly purified polynucleotides derived from salmon DNA. These polynucleotides are biocompatible with human skin and are used to support tissue repair, hydration and collagen production.
Can I Have Polynucleotide Treatment If I Have a Fish Allergy?
Because REJURAN® is derived from salmon DNA, patients with fish allergies should discuss this with their practitioner before treatment. A full consultation is always recommended to assess suitability and safety.
